Roma opened their Champions League campaign with a 1–1 draw against Fenerbahce in Istanbul on 8 September. Bryan Cristante gave Roma the lead in the 39th minute with a clinical finish at the far post, but Fenerbahce equalised just three minutes into the second half when Brown capitalised on a Greenwood through-ball. The match was played in an intense atmosphere at the Şükrü Saracoğlu Stadium, characterised by few clear-cut chances and limited space despite Roma's dominance in possession during the opening 45 minutes.
Gasperini fielded a back three of Mancini, N'Dicka and Hermoso, with Rensch and Wesley as wing-backs. Cristante and Koné anchored midfield, while Soulé, Dybala and Malen led the attack in a 3-4-2-1 formation. Cristante's performance earned particular praise for his composure in tight spaces, though Mancini struggled with his positioning on Fenerbahce's goal. Mile Svilar made crucial saves to keep Roma in the contest, notably denying Muriqi at close range and producing an exceptional reaction stop from Aydin's effort. Late in the match, the referee reviewed a penalty appeal for a challenge on Dybala but ruled the contact had occurred just outside the area, and Greenwood's free-kick struck the crossbar but Brown could not capitalise on the rebound.
Forza Roma notes that this marked Roma's return to the Champions League for the first time in over seven years, having qualified by finishing third in Serie A. The Friedkin ownership underscored their commitment to the project, with Corbin Friedkin, brother of vice-president Ryan Friedkin, present in the stands. Gasperini emphasised the club's aim to be themselves: "What I can ask is for us to be ourselves, because we have arrived to play it with our characteristics and with what we had put on the pitch during the year."
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