Roma face Genoa on 17 October at 20:45 at the Olimpico, just two days after their Champions League defeat to Real Madrid. Head coach Gian Piero Gasperini confirmed significant injury concerns at his pre-match press conference. Manu Koné has sustained a first-degree muscle strain and will miss the Genoa fixture, with hopes of recovery for the Sassuolo match before the international break. Paulo Dybala is sidelined by calf muscle fatigue and is expected to return within the coming week, meaning he will also likely sit out Saturday's match. Additionally, Bryan Cristante is being assessed and could return against Napoli or shortly after, while Donyell Malen is suspended.
With squad depth severely tested, Gasperini indicated that Santiago Castro will start in attack and that Lorenzo Pellegrini could drop into midfield to manage the fixture congestion. The coach expressed confidence in Castro despite limited recent opportunities: "He is a player of value, he has already played our championship and done so very well. Tomorrow is a good opportunity for him." Gasperini warned that Roma's stretched resources mean young Primavera players may make their debuts in certain positions. Forza Roma reports that Koné collapsed to the ground in tears during the match, consoled by French teammates, with recovery potentially extending beyond the mid-November international break.
Reflecting on Roma's recent form, Gasperini acknowledged the psychological impact of the Real Madrid collapse, where Roma led 3–1 before conceding three goals in seven minutes. "The setback exists," he said, but stressed that the squad "should not feel the need to necessarily win the Champions League or the title." With four matches in ten days ahead, Gasperini emphasized that squad rotation is essential: "We must necessarily broaden the squad; someone like Castro, Rodrigo Mora or others who will play need to acquire the same confidence and strength."
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