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Mario Hermoso trained with the squad on 17 September after missing a session on 16 September with an ankle contusion, and will be available for the upcoming fixture. Head coach Gian Piero Gasperini must decide between Evan N'Dicka and Leonardo Balerdi for the centre of defence, with N'Dicka appearing favoured, though Balerdi's defensive recovery pace offers an alternative consideration. Emanuele Lulli and Nahuel Molina are also competing for the right-back position, tasked with containing opposition wide attacks. Gasperini may deploy Matías Soulé in attack or alternatively use Niccolò Pisilli as a number 10, a choice that would allow him to field three midfielders and maintain numerical balance in defensive phases.

Gian Piero Gasperini has urged Roma to focus on daily improvement rather than chase trophy talk after a perfect start to the season. Speaking to Sky Sport ahead of the Inter fixture, the coach said: "I hoped for it more than I expected it. Today we are a squad that knows itself better than at the start of last season and we have already assimilated many things." On title ambitions, he was emphatic: "The bar does not rise by setting objectives, but by improving every day. You can only talk of targets after around twenty matches." Gasperini praised Leonardo Balerdi's immediate impact as a professional "ready to contribute straight away" and highlighted the group's balance: "The young players bring freshness, the more experienced are an example every day. It is a squad that feeds itself." Mario Hermoso trained fully with the group on 17 September after undergoing differentiated work the previous day for a mild ankle contusion, and is on course to be available for the match against Inter on Saturday 19 September at 18:00 at the Stadio Olimpico. Gasperini spoke of upcoming fixtures against Inter, Como and Real Madrid, saying: "We have earned the chance to face these teams. They will be important matches to understand what we are truly capable of." Rodrigo Mora, who arrived from Porto in the summer, has already won over supporters. The Portuguese midfielder scored his first Serie A goal against Lecce and told Sky Sport of his reasons for joining: "Roma is a very prestigious club and the style of play it proposes was one of the main reasons why I chose to come. Playing in the Champions League is an important step for my career." On his relationship with Gasperini, Mora added: "He is a very demanding coach with the whole squad, but that pushes you to grow every day." Reflecting on his first goal in giallorosso colours, he said: "It was a special moment. I like to score, but my aim is above all to help the team with goals, assists and everything needed to win."

Mario Hermoso has returned to full training with Roma's squad after working separately on 16 September due to a slight ankle contusion. The defender completed the entire session without problems and will be available for Saturday's match against Inter at the Stadio Olimpico, which kicks off at 18:00. Roma continue preparations for the fixture with head coach Gian Piero Gasperini providing an injury update on 17 September at Trigoria. Hermoso's return to availability is a boost for the big match, with the defender having missed only the previous day's session as a precaution.

Roma host Inter at the Stadio Olimpico on Saturday 19 September at 18:00 in Serie A's fifth round, a clash between the only two unbeaten sides after four matches. Both teams arrive with 12 points from four wins apiece—Roma's latest a 2–0 victory at Torino, Inter's a 5–3 comeback win over Udinese. Roma lead on goal difference in what marks the first genuine test of the season for two sides in outstanding form. Gian Piero Gasperini reports a fully fit squad for the match. Evan N'Dicka has recovered from a gastrointestinal issue, Wesley from a knock to his ankle, and Mario Hermoso from a contusion sustained during the week. Lorenzo Pellegrini is back in full training after two weeks out and available for selection, though likely as a substitute. Gasperini has deployed a 3–4–2–1 formation in recent games and may continue it here, weighing whether to use Niccolò Pisilli as a secondary forward alongside Paulo Dybala behind Donyell Malen, or to maintain Matías Soulé in that role for greater midfield cover against Inter's attack. At fullback, a contest remains between Emanuele Lulli and Nahuel Molina on the right, with Lulli slightly favored, while Wesley returns on the left. Bryan Cristante and Manu Koné are expected to form the midfield partnership. In defence, Gianluca Mancini, N'Dicka and Hermoso are lined up to start, though Leonardo Balerdi continues to press the Ivorian after recent strong displays. Inter, managed by Cristian Chivu, are without key midfield figure Hakan Calhanoglu, sidelined by a right adductor muscle strain and unavailable until after the international break. John Stones is also absent with a hamstring issue, and Denzil Spence is not yet ready. Josep Martinez is expected to retain the goalkeeper role despite some recent lapses. The back three should feature Yann Bisseck, Mohammed Akanji and Alessandro Bastoni. On the right, Luis Henrique is favored over the fatigued Diouf, while Federico Dimarco returns at left-back. Piotr Zielinski takes Calhanoglu's role in midfield alongside Nicolò Barella and Curtis Jones, who is preferred to Henrikh Mkhitaryan and Mario Sucic. Lautaro Martinez, rested against Udinese, will start alongside Marcus Thuram in attack. Betting markets show an extremely tight contest, with Inter marginally favored: Roma victory is quoted at 2.70–2.76, a draw at 3.35–3.50, and Inter at 2.50–2.60. Over 2.5 goals trades at 1.60, reflecting both teams' attacking prowess, though Roma have shown superior defensive solidity so far. The match is exclusive to DAZN, available through the app on smart TVs, smartphones, tablets, consoles and computers, with no broadcast on standard Sky Sport channels. Referee is Davide Massa, assisted by Meli and Berti, fourth official Maresca, VAR Mazzoleni, and assistant VAR Di Paolo.

Gian Piero Gasperini has acknowledged Inter's superior record ahead of tomorrow's meeting between the sides, saying: "Inter are stronger in points earned and victories. We must have the serenity to recognise these objective situations. We must look at ourselves, not others." He added that Roma are content with their progress and have improved since last season, with Lorenzo Pellegrini now in his second week of full training and available for selection. Mile Svilar, speaking to Il Corriere della Sera, addressed speculation about a Juventus move and Roma's title ambitions. "I never had even one conversation with Juventus," he said. "I'm not someone who signs a renewal and then denies the choice." On the scudetto: "Two good matches here and we're exalted; one defeat and it's drama. We must stay balanced. We'll understand later if we're truly title contenders. We're playing better, more dominant, more as a team. In Gasperini's second year his ideas come automatically." Leonardo Balerdi, recently called up to Argentina's national squad, described his Roma move as a dream realised. "I wanted to change air after many years at Marseille," he told Il Tempo. "I've wanted to play in Serie A since childhood and now at Roma I'm more than happy. I get on well with Gasperini's instructions; I feel myself improving physically every day. His way of training is an advantage because in matches I feel strong." Series A will pause after matchday five for a 20-day international break. Italy's Nations League fixtures run 25 September (Belgium), 28 September (Turkey), 2 October (France) and 5 October (Turkey). Gianluca Mancini, Bryan Cristante and Daniele Ghilardi are in the senior squad; Niccolò Pisilli and Emanuele Lulli have been called to the Under-21. Manu Koné and Donyell Malen are also engaged internationally with France and the Netherlands respectively.

Leonardo Balerdi is expected to start in defence for Roma against Inter, taking a place alongside one of Evan N'Dicka or Mario Hermoso. Wesley will play on the left side of the defence, while Matías Soulé and Paulo Dybala will support Donyell Malen in attack. The fixture will be played at the Olimpico, where over 60,000 spectators are expected. Gates will open from 15:30. Nahuel Molina and Emanuele Lulli remain in contention for selection, with one set to feature in the squad.